Details
4-Chlorobutyryl chloride 4635-59-0 with purity >99% Low price in stock
- Molecular Formula: C4H6Cl2O
- Molecular Weight: 140.997
- Appearance/Colour: colorless to light yellow liquid
- Vapor Pressure: 3 mm Hg ( 20 °C)
- Melting Point: -47 °C
- Refractive Index: 1.4610-1.4620
- Boiling Point: 174.3 °C at 760 mmHg
- Flash Point: 70.2 °C
- PSA： 17.07000
- Density: 1.231 g/cm3
- LogP: 1.77080
4-Chlorobutyryl chloride(Cas 4635-59-0) Usage
|
Flammability and Explosibility |
Nonflammable |
InChI:InChI=1/C4H6Cl2O/c5-3-1-2-4(6)7/h1-3H2
4635-59-0 Relevant articles
-
Loftfield
, p. 1365 (1951)
-
Intramolecular Cyclization of Brominated Oxime Ether Promoted with Ytterbium(0) to the Synthesis of Cyclic Imines
Wang, Yiqiong,Huang, Fei,Zhang, Songlin
supporting information, p. 5178 - 5181 (2020/08/13)
The first utility of ytterbium(0) as a m...
Monoterpenoid-based inhibitors of filoviruses targeting the glycoprotein-mediated entry process
Baev, Dmitriy S.,Maksyutov, Rinat A.,Mordvinova, Ekaterina D.,Pyankov, Oleg V.,Salakhutdinov, Nariman F.,Shcherbakov, Dmitriy N.,Shcherbakova, Nadezhda S.,Sokolova, Anastasiya S.,Tolstikova, Tatyana G.,Yarovaya, Olga I.,Zaykovskaya, Anna V.,Zybkina, Anastasiya V.
, (2020/09/09)
In this study, we screened a large libra...
FGFR INHIBITOR AND APPLICATION THEREOF
-
Paragraph 0249-0250, (2020/01/22)
An azatricyclic compound (as represented...
Method for long-term stable preparation of 4-chlorobutyryl chloride
-
Paragraph 0042-0068, (2020/08/27)
The invention relates to a synthesis met...
4635-59-0 Process route
-
-
96-48-0
4-butanolide
-
-
4635-59-0
4-Chlorobutanoyl chloride
| Conditions | Yield |
|---|---|
|
With
bis(trichloromethyl) carbonate; Al(3+)*3H2O4P(1-)*CH5N;
In
toluene;
at 80 ℃;
for 3h;
Solvent;
Reagent/catalyst;
Large scale;
|
94.1%
|
|
With
thionyl chloride; zinc(II) chloride;
at 55 ℃;
for 12h;
|
74%
|
|
With
thionyl chloride; zinc(II) chloride;
at 55 ℃;
for 12h;
|
74%
|
|
With
thionyl chloride; zinc(II) chloride;
for 6h;
Heating;
|
70%
|
|
With
thionyl chloride; zinc(II) chloride;
at 55 ℃;
for 22h;
|
65%
|
|
With
hydrogenchloride;
anschliessend mit Thionylchlorid;
|
|
|
With
thionyl chloride; zinc(II) chloride;
|
|
|
With
phosphorus pentachloride; zinc(II) chloride;
|
|
|
With
thionyl chloride; zinc(II) chloride;
at 60 - 70 ℃;
|
|
|
With
thionyl chloride; sulfuric acid;
|
|
|
With
thionyl chloride; zinc(II) chloride;
|
|
|
With
thionyl chloride;
for 2h;
Heating;
|
|
|
With
thionyl chloride; zinc(II) chloride;
Heating;
|
|
|
With
thionyl chloride; zinc(II) chloride;
Heating;
|
|
|
With
Dichloromethyl methyl ether; zinc(II) chloride;
at 60 ℃;
for 2h;
|
|
|
With
phosgene;
|
|
|
With
thionyl chloride; zinc(II) chloride;
at 60 ℃;
for 5h;
|
-
-
627-00-9
γ-chlorobutyric acid
-
-
4635-59-0
4-Chlorobutanoyl chloride
| Conditions | Yield |
|---|---|
|
With
thionyl chloride;
Heating;
|
97%
|
|
With
thionyl chloride;
In
benzene;
for 0.5h;
Heating;
water-bath;
|
58%
|
|
With
thionyl chloride;
|
|
|
With
thionyl chloride; Petroleum ether;
|
|
|
With
phosphorus pentachloride;
|
|
|
With
thionyl chloride;
In
dichloromethane;
at 20 ℃;
for 16h;
|
|
|
With
thionyl chloride;
In
ethanol;
at 0 ℃;
for 2h;
Reflux;
|
|
|
With
thionyl chloride;
In
N,N-dimethyl-formamide;
at 70 ℃;
for 1.5h;
|
|
|
With
thionyl chloride;
at 25 ℃;
for 2h;
Reflux;
|
|
|
With
oxalyl dichloride;
In
dichloromethane;
at 0 - 20 ℃;
for 2h;
|
|
|
With
oxalyl dichloride; N,N-dimethyl-formamide;
In
dichloromethane;
Inert atmosphere;
|
|
|
With
thionyl chloride;
at 100 ℃;
for 4h;
Inert atmosphere;
|
|
|
With
oxalyl dichloride; N,N-dimethyl-formamide;
In
dichloromethane;
at 20 ℃;
for 4h;
Inert atmosphere;
|
|
|
With
thionyl chloride;
for 2h;
Reflux;
|
|
|
With
thionyl chloride;
for 2h;
Reflux;
Inert atmosphere;
|
|
|
With
oxalyl dichloride; N,N-dimethyl-formamide;
In
dichloromethane;
at 20 ℃;
for 4h;
Inert atmosphere;
|
|
|
With
oxalyl dichloride; N,N-dimethyl-formamide;
In
dichloromethane;
at 0 - 20 ℃;
for 1h;
|
4635-59-0 Upstream products
-
96-48-0
4-butanolide
-
56-23-5
tetrachloromethane
-
75-44-5
phosgene
-
4885-02-3
Dichloromethyl methyl ether
4635-59-0 Downstream products
-
79386-90-6
1,5-Dichloro-2-pentanone
-
69966-83-2
4-chloro-1-(morpholin-4-yl)butan-1-one
-
191168-66-8
N-(p-tolyl)-4-chlorobutyramide
-
7152-03-6
p-methoxyphenyl cyclopropyl ketone
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