Niraparib

  • CAS:1038915-60-4
  • purity:99%
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1.What is the Niraparib ?

(S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-carboxamide is also known as MK-4827(Niraparib) tosylate is a selective inhibitor of PARP1/PARP2 (The poly(ADP-ribose) polymerase) with great activity in cancer cells with mutant BRCA-1 and BRCA-2. It has been recently approved by FDA for the maintenance treatment of adult patients with recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancer who are in complete or partial response to platinum-based chemotherapy. In vitro studies have shown that niraparib-induced cytotoxicity may involve inhibition of PARP enzymatic activity and increased formation of PARP-DNA complexes resulting in DNA damage, apoptosis and cell death.

2.What is the CAS number for Niraparib ?

The CAS number of Niraparib is 1038915-60-4.

3.What are another words for Niraparib ?

Synonyms?for?Niraparib 1038915-60-4:(S)-2-(4-(Piperidin-3-yl)phenyl)-2H-indazole-7-carboxamide

4.What is Niraparib (1038915-60-4) used for?

Niraparib is a novel oral poly(ADP-ribose)polymerase (PARP) inhibitor efficacious in BRCA-1 and -2 mutant tumors.

Relevant articles related to Niraparib:

Article

Source

Niraparib preparation method

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, (2021/11/14)

NIRAPARIB SALTS

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Paragraph 000404-000406, (2020/05/15)

New method for preparing niraparib and intermediate thereof

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Paragraph 0024-0028, (2019/09/14)

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