DEOXYNIVALENOL

  • CAS:51481-10-8
  • purity:99%
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1.What is the DEOXYNIVALENOL ?

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4-deoxy Nivalenol is a trichothecene mycotoxin that has been found in Fusarium. It binds to eukaryotic ribosomes and inhibits protein synthesis in mice when administered at doses ranging from 5 to 25 mg/kg. 4-deoxy Nivalenol (0.1 and 0.2 mg/kg) induces emesis in pigs and decreases feed consumption in pigs when administered at a dose of 40 ppb in the diet. It induces lethality in mice (LD50 = 46-78 mg/kg). 4-deoxy Nivalenol has been found in F. graminearum-infected cereal grains such as wheat, barley, and corn.

2.What is the CAS number for DEOXYNIVALENOL ?

The CAS number of DEOXYNIVALENOL is 51481-10-8.

3.What are another words for DEOXYNIVALENOL ?

Synonyms?for?DEOXYNIVALENOL 51481-10-8:Spiro[2,5-methano-1-benzoxepin-10,2'-oxirane],trichothec-9-en-8-one deriv.; 4-Deoxynivalenol; 4-Desoxynivalenol; DON;Dehydronivalenol; Deoxynivalenol; NSC 269144; Vomitoxin

4.What is DEOXYNIVALENOL (51481-10-8) used for?

Deoxynivalenol is a tricothecene mycotoxin and potent protein synthesis inhibitor. Deoxynivalenol exhibits cytotoxic activity in vivo via the ribotoxic stress response. Deoxynivalenol induces p38-mediated gene expression and apoptosis in leukocytes; activity results in systemic expression of interleukin-6 (IL-6) and other proinflammatory cytokines. Also induces migration of NF-κB into the nucleus.

InChI:InChI=1/C15H20O6/c1-7-3-9-14(5-16,11(19)10(7)18)13(2)4-8(17)12(21-9)15(13)6-20-15/h3,8-9,11-12,16-17,19H,4-6H2,1-2H3/t8-,9-,11-,12-,13-,14-,15-/m1/s1

Relevant articles related to DEOXYNIVALENOL:

Article

Source

Sulfation of deoxynivalenol, its acetylated derivatives, and T2-toxin

Fruhmann, Philipp,Skrinjar, Philipp,Weber, Julia,Mikula, Hannes,Warth, Benedikt,Sulyok, Michael,Krska, Rudolf,Adam, Gerhard,Rosenberg, Erwin,Hametner, Christian,Fr?hlich, Johannes

, p. 5260 - 5266 (2014/07/08)

Structure-activity relationships of trichothecene toxins in an Arabidopsis thaliana leaf assay

Desjardins, Anne E.,McCormick, Susan P.,Appell, Michael

, p. 6487 - 6492 (2008/09/19)

Trichothecene mycotoxin interconversions: Partial syntheses of calonectrin and deoxynivalenol, and of a trichothecene epi-epoxide, 3α,4β,15-triacetoxy-12,13-epi-epoxytrichothec-9-ene

Cameron,Colvin

, p. 887 - 895 (2007/10/02)

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