Olesoxime

  • CAS：22033-87-0
  • purity：99%
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What is the Olesoxime ?

Olesoxime is , while it's Molecular Formula is C27H45NO. TRO 19622 has been used as a mitochondrial permeability transition pore inhibitor in mouse neurons2. TRO 19622 is also known to stimulate myelin repair in rat models of demyelination3.

What is the CAS number for Olesoxime ?

The CAS number of Olesoxime is 22033-87-0.

More information of Olesoxime 22033-87-0 are:

Synonyms

NSC 21311;Olesoxime;TRO 19622;

CAS?Number

22033-87-0

Molecular Formula

C27H45NO

Molecular Weight

399.66

Density

1.10g/cm3

Melting Point

145-148 ºC

Boiling Point

510 °C at 760 mmHg

Flash Point

341 °C

PSA

32.59000

LogP

7.85800

Pka

12.27±0.70(Predicted)

What is Olesoxime (22033-87-0) used for?

TRO19622 (22033-87-0) is a neuroregenerative and neuroprotective agent acting at components of the mitochondrial permeability transition pore (MPTP).1?Rescues motor neurons from axotomy-induced cell death and promotes nerve regeneration following sciatic nerve crush in mice. Reduces ROS and NLRP3 inflammasome activation in a mouse model of intracerebral hemorrhage.2?Inhibits MPTP opening and protects neurons from apoptosis.3?Induces oligodendrocyte maturation in culture and promotes myelin regeneration?in vivo?in a rodent model.4

InChI:InChI=1/C27H45NO/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28-29)13-15-26(20,4)25(22)14-16-27(23,24)5/h17-19,22-25,29H,6-16H2,1-5H3/b28-21+

Articles related to Olesoxime:

Article

Source

Convenient preparation of A-ring fused pyridines from steroidal enamides

Barthakur, Madan G.,Borthakur, Moyurima,Boruah, Romesh C.

, p. 1137 - 1142 (2008/12/22)

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