Valrubicin

Quality Manufacturer Supply High Purity 99% Valrubicin 56124-62-0 with Reasonable Price We provide high quality Valrubicin (CAS 56124-62-0), at a very affordable prices to our customers.

1.What is the Valrubicin ?

Valrubicin was launched as a new 'chemotherapeutic agent for the treatment of bladder cancer, particularly in patients with BCG-refractory carcinoma in situ (CIS) of the bladder for whom immediate cystectomy is unacceptable. It belongs to the class of anthracyclines, the widest used in human cancers, and is a N-trifluoroacetyl 14-valerate derivative of doxorubicin.Valrubicin can be obtained in 3 steps from daunomycin by N-trifluoroacetylation of the sugar moiety then iodination of the 2-acetyl group and introduction of a valerate residue. A proposed mechanism involved in the cytotoxicity of Valrubicin coud be the blockade of SV40 large T antigen helicase; this cellular enzyme is involved in the formation of a ternary complex with DNA to maintain the topographic structure of DNA during transcription. In patients with CIS of bladder refractory to front line and second line therapies, intravesical instillation of Valrubicin resulted in a complete response with a significant rate and allowed a delay in cystectomy. Systemic absorption was minimal and accordingly produced a lower incidence of cardiotoxicity compared with doxorubicin.

Chemotherapy drug used to treat cancer of the bladder.

2.What is the CAS number for Valrubicin ?

The CAS number of Valrubicin is 56124-62-0.

More information of Valrubicin 56124-62-0 are:

3.What is the molecular formula of Valrubicin ?

The chemical formula of?Valrubicin is C34H36F3NO13 which containing 34 Carbon atoms,36 Hydrogen atoms,3 Fluorine atoms,1 Nitrogen atoms and 13 Oxygen atoms,and the molecular weight, and the molecular weight of Valrubicin is 723.654

4.What is Valrubicin(56124-62-0)used for?

Valrubicin was launched as a new 'chemotherapeutic agent for the treatment of bladder cancer, particularly in patients with BCG-refractory carcinoma in situ (CIS) of the bladder for whom immediate cystectomy is unacceptable. It belongs to the class of anthracyclines, the widest used in human cancers, and is a N-trifluoroacetyl 14-valerate derivative of doxorubicin.Valrubicin can be obtained in 3 steps from daunomycin by N-trifluoroacetylation of the sugar moiety then iodination of the 2-acetyl group and introduction of a valerate residue. A proposed mechanism involved in the cytotoxicity of Valrubicin coud be the blockade of SV40 large T antigen helicase; this cellular enzyme is involved in the formation of a ternary complex with DNA to maintain the topographic structure of DNA during transcription. In patients with CIS of bladder refractory to front line and second line therapies, intravesical instillation of Valrubicin resulted in a complete response with a significant rate and allowed a delay in cystectomy. Systemic absorption was minimal and accordingly produced a lower incidence of cardiotoxicity compared with doxorubicin.

InChI:InChI=1/C34H36F3NO13/c1-4-5-9-21(40)49-13-20(39)33(47)11-16-24(19(12-33)51-22-10-17(27(41)14(2)50-22)38-32(46)34(35,36)37)31(45)26-25(29(16)43)28(42)15-7-6-8-18(48-3)23(15)30(26)44/h6-8,14,17,19,22,27,41,43,45,47H,4-5,9-13H2,1-3H3,(H,38,46)/t14-,17-,19-,22-,27+,33-/m0/s1

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5.Quality Manufacturer Supply High Purity 99% Valrubicin 56124-62-0 with Reasonable Price

TIANJIN COOKMAN CHEMICAL IMP & EXP CO.,LTD. is a quality supplier of Valrubicin. Our main goal is customer satisfaction. Contact us to negotiate the best price for your business on Valrubicin 56124-62-0.